WebThe purposes of this study were to investigate the effects of B cell translocation gene 2 (BTG2) on the proliferation, apoptosis, and invasion of triple-negative breast cancer … WebMar 21, 2024 · BTG2 (BTG Anti-Proliferation Factor 2) is a Protein Coding gene. Diseases associated with BTG2 include Diffuse Large B-Cell Lymphoma Activated B-Cell Type …
Did you know?
WebMigration and invasion enhancer 1 (MIEN1/C35/C17orf37), as an oncogenic gene, is located on chromosome 17q12 and 505 nucleotides from the 3′ end of the ERBB2 oncogene [1,2].Several studies have shown that MIEN1 overexpression results in either disease progression or metastatic propensity in many tumor types, including colon, prostate, … WebBTG2 treatment exhibited inhibitory effect on PI3K/Akt pathway in MCF-7/ADR cells. Significance miR-27a-3p might be associated with resistance of breast cancer cells to adriamycin treatments, modulating cell proliferation and apoptosis by targeting BTG2 and promoting the PI3K/Akt pathway in breast cancer cells. miR-27a-3p/BTG2 axis might be …
WebA functional and biochemical interaction of TIS21(/BTG2/PC3) with Forkhead box M1 (FoxM1), essential transcription factor for hepatocyte regeneration and a master regulator of mitotic gene expression, was explored. ... Forced expression of TIS21 impaired growth, proliferation, and tumorigenic potential of Huh7 cells. At the mechanistic level ... WebDownload scientific diagram Btg2 Downregulation Leads to Increased Microglia Proliferation (A) Normalized read count of genes involved in microglia proliferation (Hammond et al., 2024).
WebMar 13, 2024 · Hwang et al. report that the transcription factors BTG1 and BTG2 are selectively expressed in quiescent T cells. In mice, T cells conditionally knocked out for both factors showed enhanced proliferation and a lowered threshold of activation both in vitro and in response to Listeria monocytogenes infection. Deficiency of BTG1 and BTG2 … WebFeb 25, 2016 · BTG2 interacts with CAF1 deadenylase through its APRO domain, a defining feature of BTG/Tob factors. ... Importantly, we also show that the interaction of BTG2 with the first RRM domain of PABPC1 is required for BTG2 to control cell proliferation. Publication types Research Support, Non-U.S. Gov't MeSH terms Blotting, Western ...
WebThus, the mutation of BTG2 may result in the dysfunction of tumor-repressor role of BTG2, and thereby contribute to malignant proliferation of B-cells in PT-DLBCL. In addition, we observed that 24% of patients were mutated in PRDM1 and were associated with shorter OS ( P =0.040, Table 3 ).
WebMar 6, 2012 · The objective of the study was to investigate the impact of the B cell translocation gene 2 (BTG2) on lung cancer cell growth, proliferation, metastasis, and other biological characteristics and to provide experimental evidence for the biological treatment of human lung cancer. A pcDNA3.1-BTG2 eukaryotic expression vector was … assurant japan株式会社Protein BTG2 also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the BTG2 gene (B-cell translocation gene 2) and in other mammals by the homologous Btg2 gene. This protein controls cell cycle … See more A number of studies in vivo have shown that BTG2 expression is associated with the neurogenic asymmetric division in neural progenitor cells. Tis21-GFP has been used as a neurogenic marker because it is not expressed until … See more BTG2 has been shown to inhibit medulloblastoma, the very aggressive tumor of cerebellum, by inhibiting the proliferation and triggering the differentiation of the … See more • Puisieux A, Magaud JP (April 1999). "[Mechanisms of BTG2 activity, a transcriptional target of p53: evidences and hypothesis]". Bulletin du Cancer. 86 (4): 358–64. See more BTG2 has been shown to interact with PRMT1, HOXB9, CNOT8 and HDAC1 HDAC4 and HDAC9. It has also been studied with See more • Human BTG2 genome location and BTG2 gene details page in the UCSC Genome Browser. • Overview of all the structural information … See more assurant jobs linkedinWebFeb 15, 2012 · L-Mimosine, an iron chelator and a prolyl 4-hydroxylase inhibitor, blocks many cancer cells at the late G1 phase. B-cell translocation gene 2 (Btg2) regulates the G1/S transition phases of the cell cycle. N-myc downstream regulated gene 1 (Ndrg1) is a differentiation-inducing gene upregulated by hyp … assurant japanWebWe revealed that the mechanism of PRMT5-induced proliferation was partially mediated by BTG downregulation, leading to cell cycle arrest during the G1 phase in HCC cells. Ectopic BTG2 overexpression decreased HCC growth, caused cell cycle arrest at the G1 phase, and downregulated Cyclin D1 and Cyclin E1 protein expression. assurance opel mokkaWebHowever, BTG2 may be cancer type-dependent, as overexpression of BTG2 has been demonstrated to suppress the proliferation of pancreatic and lung cancer cells, but promote the proliferation of bladder cancer cells. Since the association between BTG2 and luminal A-subtype breast cancer remains unclear, it is important to understand the biological ... assurant kolkataWebThe B cell translocation gene 1 (BTG1) and BTG2 play a key role in a wide range of cellular activities including proliferation, apoptosis, and cell growth via modulating a variety of central biological steps such as transcription, post-transcriptional, and translation. BTG1 and BTG2 have been identi … assurance nissan skyline r34WebThe growth and development of oocyte affect the functional activities of the surrounding somatic cells. These cells are regulated by various types of hormones, proteins, metabolites, and regulatory molecules through gap communication, ultimately leading to the development and maturation of oocytes. The close association between somatic cells and oocytes, … assurant linkedin