Irf5 protein half-life
WebRecombinant Human IRF5 protein See all IRF5 proteins and peptides Purity > 95 % SDS-PAGE. Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin … WebMar 29, 2024 · The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal roles in many aspects of the immune response, including immune cell development and differentiation and regulating responses to pathogens. Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream …
Irf5 protein half-life
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WebInterferon regulatory factors (IRFs) are a family of homologous proteins that regulate the transcription of interferons (IFNs) and IFN-induced gene expression. As such they are … WebInterferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of immune and homeostatic processes, including host defense against pathogens, tumorigenesis, and autoimmunity.
WebOct 5, 2008 · The physiological importance of IRF5 makes it an important prototype for investigating regulation of IRF proteins. IRF proteins, including IRF5, comprise two major domains, an N-terminal DNA... WebIRF5 is a transcription factor that functions as a central mediator of Toll-like receptor signaling and is involved in the production of type I IFN, apoptosis, cell-cycle regulation, …
WebSep 10, 2024 · IRF5 is highly expressed in not only monocytes and macrophages but also in B cells and dendritic cells. Its expression in macrophages can be upregulated in response to the inflammatory … WebHere, we designed antagonistic cell-penetrating peptides (CPPs) by incorporating the native amino acid sequence of IRF5 to directly interrogate the mechanism (s) of IRF5 activation and function in human primary immune cells. RESULTS Identification of novel CPP motifs and design of CPPs targeting IRF5
WebMar 21, 2024 · IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Systemic Lupus Erythematosus 10 and Inflammatory Bowel …
WebMar 21, 2024 · Title: Interferon regulatory factor 5‑induced upregulation of zinc‑finger protein 217 promotes pancreatic carcinoma progression. One gut microbiota, … greater manchester police neighbourhoodWebJan 20, 2014 · Interferon regulatory factor 5 (IRF5) modulates the expression of genes controlling cell growth and apoptosis. ... The increased IM sensitivity of K562 and KYO1 cells lentivirally transduced with IRF5 established that this protein could also reduce CML cell viability in response to BCR-ABL kinase inactivation. Previous evidence has shown that, ... greater manchester police people strategyWebOct 29, 2024 · Interferon regulatory factor-5 (IRF5) is a member of the IRF transcription factor family and is important for inducing the innate immune responses mediated by Toll … greater manchester police prestwichWebMar 28, 2007 · We also found, in the polyadenylation site of IRF5, an SNP (G>A) determining the length of the 3′-UTR. The A allele leads to a short 3′-UTR, while the G allele encodes for a 1.5-kb long 3′-UTR and has 2 strong AREs known to be responsible for short half-life and rapid RNA degradation . Messenger RNA with a shorter 3′-UTR bearing no such ... greater manchester police news todayWebMay 30, 2024 · Background. Community-acquired pneumonia (CAP) is a common disease with significant morbidity and mortality. Interferon regulatory factor 5 (IRF5), which induces type I interferons (IFNs) and cytokines such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-10, and interferon gamma-induced protein (IP)10, is a key transcription factor … greater manchester police recruitmentgreater manchester police postcodeWebMay 19, 2024 · IRF5 is activated by phosphorylation and ubiquitination events downstream of pattern recognition receptors (PRRs), e.g., nucleotide-binding oligomerization domain-containing protein 2 (NOD2), Toll-like receptor 2 (TLR2), and TLR4, and directly regulates many cytokines associated with IBD (IL-1β, IL-6, IL-10, IL-12, IL-23, and TNF), placing IRF5 … flint group germany gmbh ahaus