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WebWhile these safety concerns should be considered prior to the initiation of allopurinol, dose escalation beyond 300 mg/day has been proven to be safe. 29,30 To reduce the risk of AHS, starting doses should not be greater than 100 mg/day for any patient and 50 mg/day for patients with stage 4 or worse CKD. Gradual titration every 2–5 weeks is ...

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