WebSulfamethoxazole and trimethoprim, given at a common clinical dosage, increased the phenytoin half-life by 39% and decreased the phenytoin metabolic clearance rate by 27%. When administering these drugs concurrently, one should be alert for possible excessive phenytoin effect. Methotrexate WebLike methotrexate, antibiotics that contain the drug trimethoprim or sulfonamides (eg trimethoprim + sulphamethoxazole) antagonise folate. Taking them at the same time as methotrexate could increase the toxicity. Penicillins, minocycline and ciprofloxacin may also increase methotrexate toxicity.
A deadly prescription: combination of methotrexate and …
Webmethotrexate (> 1g/m2) until calcium folinate and post hydration fluids discontinued (as per methotrexate levels and protocol requirements). • Alternative prophylaxis dosing based on a patient’s body surface area (75mg/m2/dose (to a maximum of 160mg trimethoprim component) given 12 hourly on 3 days per week:(4) WebKeywords: drug interaction, methotrexate, methotrexate toxicity, pancytopenia, trimethoprim–sulphamethoxazole SUMMARY What is known and Objective: Combining methotrexate (MTX) with trimethoprim-sulfamethoxazole (TS) is associated with a potential drug interaction that increases MTX toxicity. The aim prophylactic antibiotic regimen
Co-Trimoxazole 80/400mg Tablets - Summary of Product
WebAug 8, 2024 · Methotrexate: Trimethoprim may enhance the adverse/toxic effect of Methotrexate. Management: Consider avoiding concomitant use of methotrexate and either sulfamethoxazole or trimethoprim. If used concomitantly, monitor for the development of signs and symptoms of methotrexate toxicity (e.g., bone marrow suppression). Consider … WebMethotrexate and trimethoprim-sulfamethoxazole: toxicity from this combination continues to occur Can Fam Physician. 2014 Jan;60(1):53-6. Authors Jessica Cudmore 1 , Matthew Seftel, Jeffrey Sisler, Ryan Zarychanski. Affiliation 1 University of ... WebMar 1, 2024 · Trimethoprim (trimethoprim (trimethoprim tablet) tablet) can interfere with a serum methotrexate assay as determined by the Competitive Binding Protein Technique … prophylactic antibiotics for cat scratch